Zinc finger protein 253 (ZNF253)

About Zinc finger protein 253

Zinc finger protein 253 (ZNF253) is a protein from Homo sapiens identified by UniProt accession O75346, 499 residues long. MolForge cross-references it against 0 known binders and 7 disease associations.

Target properties

Protein name	Zinc finger protein 253
UniProt accession	O75346
Gene	ZNF253
Organism	Homo sapiens
Length	499 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (7)

Diseases linked to this target (Open Targets).

Down syndrome · score 0.05
serum metabolite measurement · score 0.03
body fat percentage · score 0.02
medulloblastoma · score 0.01
psoriasis · score 0.01
MALT lymphoma · score 0.00
asthma · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75346-F1	alphafold	PREDICTED	71.67	—

Amino-acid sequence (499 residues)

MGPLQFRDVA IEFSLEEWHC LDTAQRNLYR DVMLENYRNL VFLGIVVSKP DLVTCLEQGK KPLTMERHEM IAKPPVMSSH FAQDLWPENI QNSFQIGMLR RYEECRHDNL QLKKGCKSVG EHKVHKGGYN GLNQCLTTTQ KEIFQCDKYG KVFHKFSNSN TYKTRHTGIN LFKCIICGKA FKRSSTLTTH KKIHTGEKPY RCEECGKAFN QSANLTTHKR IHTGEKPYRC EECGKAFKQS SNLTTHKKIH TGEKPYKCEE CGKAFNRSTD LTTHKIVHTG EKPYKCEECG KAFKHPSHVT THKKIHTRGK PYNCEECGKS FKHCSNLTIH KRIHTGEKPY KCEECGKAFH LSSHLTTHKI LHTGEKPYRC RECGKAFNHS TTLFSHEKIH TGEKPYKCDE CGKTFTWPSI LSKHKRTHTG EKPYKCEECG KSFTASSTLT THKRIHTGEK PYKCEECGKA FNWSSDLNKH KKIHIERKPY IVKNVTDLLN VPPLLISIR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards