Vacuolar protein sorting-associated protein 4B (VPS4B)

About Vacuolar protein sorting-associated protein 4B

Vacuolar protein sorting-associated protein 4B (VPS4B) is a protein from Homo sapiens identified by UniProt accession O75351, 444 residues long. MolForge cross-references it against 0 known binders and 91 disease associations.

Target properties

Protein name	Vacuolar protein sorting-associated protein 4B
UniProt accession	O75351
Gene	VPS4B
Organism	Homo sapiens
Length	444 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (91)

Diseases linked to this target (Open Targets).

HIV infection · score 0.46
dentin dysplasia type I · score 0.37
monocyte percentage of leukocytes · score 0.22
drug use measurement · score 0.10
cancer · score 0.09
reticulocyte measurement · score 0.06
eosinophil count · score 0.05
eosinophil percentage of leukocytes · score 0.04
DNA methylation · score 0.04
sex hormone-binding globulin measurement · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75351-F1	alphafold	PREDICTED	85.92	—

Amino-acid sequence (444 residues)

MSSTSPNLQK AIDLASKAAQ EDKAGNYEEA LQLYQHAVQY FLHVVKYEAQ GDKAKQSIRA KCTEYLDRAE KLKEYLKNKE KKAQKPVKEG QPSPADEKGN DSDGEGESDD PEKKKLQNQL QGAIVIERPN VKWSDVAGLE GAKEALKEAV ILPIKFPHLF TGKRTPWRGI LLFGPPGTGK SYLAKAVATE ANNSTFFSIS SSDLVSKWLG ESEKLVKNLF QLARENKPSI IFIDEIDSLC GSRSENESEA ARRIKTEFLV QMQGVGVDND GILVLGATNI PWVLDSAIRR RFEKRIYIPL PEPHARAAMF KLHLGTTQNS LTEADFRELG RKTDGYSGAD ISIIVRDALM QPVRKVQSAT HFKKVRGPSR ADPNHLVDDL LTPCSPGDPG AIEMTWMDVP GDKLLEPVVS MSDMLRSLSN TKPTVNEHDL LKLKKFTEDF GQEG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards