About Ectonucleoside triphosphate diphosphohydrolase 6
Ectonucleoside triphosphate diphosphohydrolase 6 (ENTPD6) is a protein
from Homo sapiens identified by UniProt accession
O75354, 484 residues long.
MolForge cross-references it against 0 known binders and
52 disease associations.
Target properties
| Protein name | Ectonucleoside triphosphate diphosphohydrolase 6 |
|---|
| UniProt accession | O75354 |
|---|
| Gene | ENTPD6 |
|---|
| Organism | Homo sapiens |
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| Length | 484 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (52)
Diseases linked to this target (Open Targets).
- body mass index · score 0.39
- PHF-tau measurement · score 0.28
- visceral adipose tissue measurement · score 0.26
- lean body mass · score 0.24
- C-reactive protein measurement · score 0.20
- body weight · score 0.16
- monocyte count · score 0.16
- base metabolic rate measurement · score 0.15
- vital capacity · score 0.11
- platelet count · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75354-F1 | alphafold | PREDICTED | 83.40 | — |
Amino-acid sequence (484 residues)
MKKGIRYETS RKTSYIFQQP QHGPWQTRMR KISNHGSLRV AKVAYPLGLC VGVFIYVAYI KWHRATATQA FFSITRAAPG ARWGQQAHSP LGTAADGHEV FYGIMFDAGS TGTRVHVFQF TRPPRETPTL THETFKALKP GLSAYADDVE KSAQGIRELL DVAKQDIPFD FWKATPLVLK ATAGLRLLPG EKAQKLLQKV KKVFKASPFL VGDDCVSIMN GTDEGVSAWI TINFLTGSLK TPGGSSVGML DLGGGSTQIA FLPRVEGTLQ ASPPGYLTAL RMFNRTYKLY SYSYLGLGLM SARLAILGGV EGQPAKDGKE LVSPCLSPSF KGEWEHAEVT YRVSGQKAAA SLHELCAARV SEVLQNRVHR TEEVKHVDFY AFSYYYDLAA GVGLIDAEKG GSLVVGDFEI AAKYVCRTLE TQPQSSPFSC MDLTYVSLLL QEFGFPRSKV LKLTRKIDNV ETSWALGAIF HYIDSLNRQK SPAS
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