About Ectonucleoside triphosphate diphosphohydrolase 3
Ectonucleoside triphosphate diphosphohydrolase 3 (ENTPD3) is a protein
from Homo sapiens identified by UniProt accession
O75355, 529 residues long.
MolForge cross-references it against 0 known binders and
64 disease associations.
Target properties
| Protein name | Ectonucleoside triphosphate diphosphohydrolase 3 |
|---|
| UniProt accession | O75355 |
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| Gene | ENTPD3 |
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| Organism | Homo sapiens |
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| Length | 529 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (64)
Diseases linked to this target (Open Targets).
- eosinophil percentage of leukocytes · score 0.20
- renal cell carcinoma · score 0.17
- colorectal cancer · score 0.14
- prostate cancer · score 0.11
- Familial prostate cancer · score 0.11
- prostate carcinoma · score 0.11
- blood protein measurement · score 0.10
- colorectal adenoma · score 0.10
- eosinophil count · score 0.09
- heel bone mineral density · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75355-F1 | alphafold | PREDICTED | 90.82 | — |
Amino-acid sequence (529 residues)
MFTVLTRQPC EQAGLKALYR TPTIIALVVL LVSIVVLVSI TVIQIHKQEV LPPGLKYGIV LDAGSSRTTV YVYQWPAEKE NNTGVVSQTF KCSVKGSGIS SYGNNPQDVP RAFEECMQKV KGQVPSHLHG STPIHLGATA GMRLLRLQNE TAANEVLESI QSYFKSQPFD FRGAQIISGQ EEGVYGWITA NYLMGNFLEK NLWHMWVHPH GVETTGALDL GGASTQISFV AGEKMDLNTS DIMQVSLYGY VYTLYTHSFQ CYGRNEAEKK FLAMLLQNSP TKNHLTNPCY PRDYSISFTM GHVFDSLCTV DQRPESYNPN DVITFEGTGD PSLCKEKVAS IFDFKACHDQ ETCSFDGVYQ PKIKGPFVAF AGFYYTASAL NLSGSFSLDT FNSSTWNFCS QNWSQLPLLL PKFDEVYARS YCFSANYIYH LFVNGYKFTE ETWPQIHFEK EVGNSSIAWS LGYMLSLTNQ IPAESPLIRL PIEPPVFVGT LAFFTAAALL CLAFLAYLCS ATRRKRHSEH AFDHAVDSD
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