About Nucleoside diphosphate phosphatase ENTPD5
Nucleoside diphosphate phosphatase ENTPD5 (ENTPD5) is a protein
from Homo sapiens identified by UniProt accession
O75356, 428 residues long.
MolForge cross-references it against 0 known binders and
183 disease associations.
Target properties
| Protein name | Nucleoside diphosphate phosphatase ENTPD5 |
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| UniProt accession | O75356 |
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| Gene | ENTPD5 |
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| Organism | Homo sapiens |
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| Length | 428 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (183)
Diseases linked to this target (Open Targets).
- familial steroid-resistant nephrotic syndrome with sensorineural deafness · score 0.55
- blood protein measurement · score 0.22
- genetic disorder · score 0.19
- apolipoprotein B measurement · score 0.19
- ectonucleoside triphosphate diphosphohydrolase 5 measurement · score 0.17
- mean corpuscular volume · score 0.14
- mean corpuscular hemoglobin · score 0.12
- mean corpuscular hemoglobin concentration · score 0.12
- aspartate aminotransferase measurement · score 0.12
- erythrocyte count · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75356-F1 | alphafold | PREDICTED | 87.36 | — |
Amino-acid sequence (428 residues)
MATSWGTVFF MLVVSCVCSA VSHRNQQTWF EGIFLSSMCP INVSASTLYG IMFDAGSTGT RIHVYTFVQK MPGQLPILEG EVFDSVKPGL SAFVDQPKQG AETVQGLLEV AKDSIPRSHW KKTPVVLKAT AGLRLLPEHK AKALLFEVKE IFRKSPFLVP KGSVSIMDGS DEGILAWVTV NFLTGQLHGH RQETVGTLDL GGASTQITFL PQFEKTLEQT PRGYLTSFEM FNSTYKLYTH SYLGFGLKAA RLATLGALET EGTDGHTFRS ACLPRWLEAE WIFGGVKYQY GGNQEGEVGF EPCYAEVLRV VRGKLHQPEE VQRGSFYAFS YYYDRAVDTD MIDYEKGGIL KVEDFERKAR EVCDNLENFT SGSPFLCMDL SYITALLKDG FGFADSTVLQ LTKKVNNIET GWALGATFHL LQSLGISH
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