Homeobox protein prophet of Pit-1 (PROP1)

About Homeobox protein prophet of Pit-1

Homeobox protein prophet of Pit-1 (PROP1) is a protein from Homo sapiens identified by UniProt accession O75360, 226 residues long. MolForge cross-references it against 0 known binders and 191 disease associations.

Target properties

Protein name	Homeobox protein prophet of Pit-1
UniProt accession	O75360
Gene	PROP1
Organism	Homo sapiens
Length	226 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (191)

Diseases linked to this target (Open Targets).

Combined pituitary hormone deficiencies, genetic forms · score 0.82
hypopituitarism · score 0.72
combined pituitary hormone deficiencies, genetic form · score 0.56
neurodegenerative disease · score 0.50
panhypopituitarism · score 0.46
genetic disorder · score 0.41
autosominal recessive combined pituitary hormone deficiency · score 0.40
hypothyroidism due to deficient transcription factors involved in pituitary development or function · score 0.38
46,XY partial gonadal dysgenesis · score 0.35
disorder of sexual differentiation · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75360-F1	alphafold	PREDICTED	69.42	—

Amino-acid sequence (226 residues)

MEAERRRQAE KPKKGRVGSN LLPERHPATG TPTTTVDSSA PPCRRLPGAG GGRSRFSPQG GQRGRPHSRR RHRTTFSPVQ LEQLESAFGR NQYPDIWARE SLARDTGLSE ARIQVWFQNR RAKQRKQERS LLQPLAHLSP AAFSSFLPES TACPYSYAAP PPPVTCFPHP YSHALPSQPS TGGAFALSHQ SEDWYPTLHP APAGHLPCPP PPPMLPLSLE PSKSWN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards