Pituitary homeobox 3 (PITX3)

About Pituitary homeobox 3

Pituitary homeobox 3 (PITX3) is a protein from Homo sapiens identified by UniProt accession O75364, 302 residues long. MolForge cross-references it against 0 known binders and 137 disease associations.

Target properties

Protein name	Pituitary homeobox 3
UniProt accession	O75364
Gene	PITX3
Organism	Homo sapiens
Length	302 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (137)

Diseases linked to this target (Open Targets).

Posterior polar cataract · score 0.73
Familial ocular anterior segment mesenchymal dysgenesis · score 0.72
anterior segment dysgenesis · score 0.62
Autosomal dominant optic atrophy and cataract · score 0.50
early-onset non-syndromic cataract · score 0.47
cataract-glaucoma syndrome · score 0.37
early-onset posterior polar cataract · score 0.37
Developmental cataract · score 0.26
genetic disorder · score 0.18
intelligence · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75364-F1	alphafold	PREDICTED	61.60	—

Amino-acid sequence (302 residues)

MEFGLLSEAE ARSPALSLSD AGTPHPQLPE HGCKGQEHSD SEKASASLPG GSPEDGSLKK KQRRQRTHFT SQQLQELEAT FQRNRYPDMS TREEIAVWTN LTEARVRVWF KNRRAKWRKR ERSQQAELCK GSFAAPLGGL VPPYEEVYPG YSYGNWPPKA LAPPLAAKTF PFAFNSVNVG PLASQPVFSP PSSIAASMVP SAAAAPGTVP GPGALQGLGG GPPGLAPAAV SSGAVSCPYA SAAAAAAAAA SSPYVYRDPC NSSLASLRLK AKQHASFSYP AVHGPPPAAN LSPCQYAVER PV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards