Protein tyrosine phosphatase type IVA 3 (PTP4A3)

About Protein tyrosine phosphatase type IVA 3

Protein tyrosine phosphatase type IVA 3 (PTP4A3) is a protein from Homo sapiens identified by UniProt accession O75365, 173 residues long. MolForge cross-references it against 0 known binders and 196 disease associations.

Target properties

Protein name	Protein tyrosine phosphatase type IVA 3
UniProt accession	O75365
Gene	PTP4A3
Organism	Homo sapiens
Length	173 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (196)

Diseases linked to this target (Open Targets).

mean platelet volume · score 0.40
platelet count · score 0.40
systolic blood pressure · score 0.35
Agents acting on the renin-angiotensin system use measurement · score 0.34
self reported educational attainment · score 0.32
lean body mass · score 0.32
body mass index · score 0.31
protein measurement · score 0.31
leukocyte count · score 0.31
body fat percentage · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75365-F1	alphafold	PREDICTED	86.86	—

Amino-acid sequence (173 residues)

MARMNRPAPV EVSYKHMRFL ITHNPTNATL STFIEDLKKY GATTVVRVCE VTYDKTPLEK DGITVVDWPF DDGAPPPGKV VEDWLSLVKA KFCEAPGSCV AVHCVAGLGR APVLVALALI ESGMKYEDAI QFIRQKRRGA INSKQLTYLE KYRPKQRLRF KDPHTHKTRC CVM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards