Core histone macro-H2A.1 (MACROH2A1)

About Core histone macro-H2A.1

Core histone macro-H2A.1 (MACROH2A1) is a protein from Homo sapiens identified by UniProt accession O75367, 369 residues long. MolForge cross-references it against 0 known binders and 115 disease associations.

Target properties

Protein name	Core histone macro-H2A.1
UniProt accession	O75367
Gene	MACROH2A1
Organism	Homo sapiens
Length	369 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (115)

Diseases linked to this target (Open Targets).

lymphocyte count · score 0.48
mean platelet volume · score 0.42
lymphocyte percentage of leukocytes · score 0.41
leukocyte count · score 0.41
neutrophil percentage of leukocytes · score 0.40
brachydactyly-elbow wrist dysplasia syndrome · score 0.37
benign prostatic hyperplasia · score 0.33
lower urinary tract symptom · score 0.33
myeloid white cell count · score 0.32
lean body mass · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75367-F1	alphafold	PREDICTED	82.88	—

Amino-acid sequence (369 residues)

MSSRGGKKKS TKTSRSAKAG VIFPVGRMLR YIKKGHPKYR IGVGAPVYMA AVLEYLTAEI LELAGNAARD NKKGRVTPRH ILLAVANDEE LNQLLKGVTI ASGGVLPNIH PELLAKKRGS KGKLEAIITP PPAKKAKSPS QKKPVSKKAG GKKGARKSKK KQGEVSKAAS ADSTTEGTPA DGFTVLSTKS LFLGQKLQVV QADIASIDSD AVVHPTNTDF YIGGEVGNTL EKKGGKEFVE AVLELRKKNG PLEVAGAAVS AGHGLPAKFV IHCNSPVWGA DKCEELLEKT VKNCLALADD KKLKSIAFPS IGSGRNGFPK QTAAQLILKA ISSYFVSTMS SSIKTVYFVL FDSESIGIYV QEMAKLDAN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards