Adapter SH3BGRL (SH3BGRL)

About Adapter SH3BGRL

Adapter SH3BGRL (SH3BGRL) is a protein from Homo sapiens identified by UniProt accession O75368, 114 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.

Target properties

Protein name	Adapter SH3BGRL
UniProt accession	O75368
Gene	SH3BGRL
Organism	Homo sapiens
Length	114 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (47)

Diseases linked to this target (Open Targets).

Alzheimer disease · score 0.32
neurodegenerative disease · score 0.32
Parkinson disease · score 0.32
multiple sclerosis · score 0.32
lysosomal storage disease · score 0.32
neoplasm · score 0.10
liver and intrahepatic bile duct neoplasm · score 0.04
acute myeloid leukemia · score 0.04
platelet count · score 0.03
cancer · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75368-F1	alphafold	PREDICTED	95.10	—

Amino-acid sequence (114 residues)

MVIRVYIASS SGSTAIKKKQ QDVLGFLEAN KIGFEEKDIA ANEENRKWMR ENVPENSRPA TGYPLPPQIF NESQYRGDYD AFFEARENNA VYAFLGLTAP PGSKEAEVQA KQQA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards