Peroxisomal membrane protein PEX14 (PEX14)

About Peroxisomal membrane protein PEX14

Peroxisomal membrane protein PEX14 (PEX14) is a protein from Homo sapiens identified by UniProt accession O75381, 377 residues long. MolForge cross-references it against 0 known binders and 71 disease associations.

Target properties

Protein name	Peroxisomal membrane protein PEX14
UniProt accession	O75381
Gene	PEX14
Organism	Homo sapiens
Length	377 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (71)

Diseases linked to this target (Open Targets).

peroxisome biogenesis disorder 13A (Zellweger) · score 0.73
Zellweger syndrome · score 0.66
peroxisome biogenesis disorder, complementation group K · score 0.48
peroxisome biogenesis disorder · score 0.46
neurodegenerative disease · score 0.45
asthma · score 0.41
breast carcinoma · score 0.38
peroxisome biogenesis disorder, complementation group 7 · score 0.37
peroxisome biogenesis disorder 11A (Zellweger) · score 0.37
lysosomal storage disease · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75381-F1	alphafold	PREDICTED	67.86	—

Amino-acid sequence (377 residues)

MASSEQAEQP SQPSSTPGSE NVLPREPLIA TAVKFLQNSR VRQSPLATRR AFLKKKGLTD EEIDMAFQQS GTAADEPSSL GPATQVVPVQ PPHLISQPYS PAGSRWRDYG ALAIIMAGIA FGFHQLYKKY LLPLILGGRE DRKQLERMEA GLSELSGSVA QTVTQLQTTL ASVQELLIQQ QQKIQELAHE LAAAKATTST NWILESQNIN ELKSEINSLK GLLLNRRQFP PSPSAPKIPS WQIPVKSPSP SSPAAVNHHS SSDISPVSNE STSSSPGKEG HSPEGSTVTY HLLGPQEEGE GVVDVKGQVR MEVQGEEEKR EDKEDEEDEE DDDVSHVDEE DCLGVQREDR RGGDGQINEQ VEKLRRPEGA SNESERD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards