About Tripartite motif-containing protein 3
Tripartite motif-containing protein 3 (TRIM3) is a protein
from Homo sapiens identified by UniProt accession
O75382, 744 residues long.
MolForge cross-references it against 0 known binders and
46 disease associations.
Target properties
| Protein name | Tripartite motif-containing protein 3 |
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| UniProt accession | O75382 |
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| Gene | TRIM3 |
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| Organism | Homo sapiens |
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| Length | 744 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (46)
Diseases linked to this target (Open Targets).
- neoplasm · score 0.10
- breast cancer · score 0.07
- Familial exudative vitreoretinopathy · score 0.06
- X-linked retinal dysplasia · score 0.05
- severe early-childhood-onset retinal dystrophy · score 0.05
- attention deficit hyperactivity disorder · score 0.04
- X-linked retinoschisis · score 0.04
- schizophrenia 15 · score 0.04
- hepatocellular carcinoma · score 0.04
- exudative vitreoretinopathy 2, X-linked · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75382-F1 | alphafold | PREDICTED | 83.13 | — |
Amino-acid sequence (744 residues)
MAKREDSPGP EVQPMDKQFL VCSICLDRYQ CPKVLPCLHT FCERCLQNYI PAQSLTLSCP VCRQTSILPE QGVSALQNNF FISSLMEAMQ QAPDGAHDPE DPHPLSVVAG RPLSCPNHEG KTMEFYCEAC ETAMCGECRA GEHREHGTVL LRDVVEQHKA ALQRQLEAVR GRLPQLSAAI ALVGGISQQL QERKAEALAQ ISAAFEDLEQ ALQQRKQALV SDLETICGAK QKVLQSQLDT LRQGQEHIGS SCSFAEQALR LGSAPEVLLV RKHMRERLAA LAAQAFPERP HENAQLELVL EVDGLRRSVL NLGALLTTSA TAHETVATGE GLRQALVGQP ASLTVTTKDK DGRLVRTGSA ELRAEITGPD GTRLPVPVVD HKNGTYELVY TARTEGELLL SVLLYGQPVR GSPFRVRALR PGDLPPSPDD VKRRVKSPGG PGSHVRQKAV RRPSSMYSTG GKRKDNPIED ELVFRVGSRG REKGEFTNLQ GVSAASSGRI VVADSNNQCI QVFSNEGQFK FRFGVRGRSP GQLQRPTGVA VDTNGDIIVA DYDNRWVSIF SPEGKFKTKI GAGRLMGPKG VAVDRNGHII VVDNKSCCVF TFQPNGKLVG RFGGRGATDR HFAGPHFVAV NNKNEIVVTD FHNHSVKVYS ADGEFLFKFG SHGEGNGQFN APTGVAVDSN GNIIVADWGN SRIQVFDSSG SFLSYINTSA EPLYGPQGLA LTSDGHVVVA DAGNHCFKAY RYLQ
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