Tubby-related protein 3 (TULP3)

About Tubby-related protein 3

Tubby-related protein 3 (TULP3) is a protein from Homo sapiens identified by UniProt accession O75386, 442 residues long. MolForge cross-references it against 0 known binders and 216 disease associations.

Target properties

Protein name	Tubby-related protein 3
UniProt accession	O75386
Gene	TULP3
Organism	Homo sapiens
Length	442 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (216)

Diseases linked to this target (Open Targets).

hepatorenocardiac degenerative fibrosis · score 0.70
neurodegenerative disease · score 0.48
ciliopathy · score 0.37
leukocyte count · score 0.27
mean corpuscular volume · score 0.25
mean corpuscular hemoglobin concentration · score 0.23
mean corpuscular hemoglobin · score 0.22
genetic disorder · score 0.19
mean reticulocyte volume · score 0.19
neutrophil count · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75386-F1	alphafold	PREDICTED	72.25	—

Amino-acid sequence (442 residues)

MEASRCRLSP SGDSVFHEEM MKMRQAKLDY QRLLLEKRQR KKRLEPFMVQ PNPEARLRRA KPRASDEQTP LVNCHTPHSN VILHGIDGPA AVLKPDEVHA PSVSSSVVEE DAENTVDTAS KPGLQERLQK HDISESVNFD EETDGISQSA CLERPNSASS QNSTDTGTSG SATAAQPADN LLGDIDDLED FVYSPAPQGV TVRCRIIRDK RGMDRGLFPT YYMYLEKEEN QKIFLLAARK RKKSKTANYL ISIDPVDLSR EGESYVGKLR SNLMGTKFTV YDRGICPMKG RGLVGAAHTR QELAAISYET NVLGFKGPRK MSVIIPGMTL NHKQIPYQPQ NNHDSLLSRW QNRTMENLVE LHNKAPVWNS DTQSYVLNFR GRVTQASVKN FQIVHKNDPD YIVMQFGRVA DDVFTLDYNY PLCAVQAFGI GLSSFDSKLA CE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards