About Large neutral amino acids transporter small subunit 3
Large neutral amino acids transporter small subunit 3 (SLC43A1) is a protein
from Homo sapiens identified by UniProt accession
O75387, 559 residues long.
MolForge cross-references it against 0 known binders and
30 disease associations.
Target properties
| Protein name | Large neutral amino acids transporter small subunit 3 |
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| UniProt accession | O75387 |
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| Gene | SLC43A1 |
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| Organism | Homo sapiens |
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| Length | 559 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (30)
Diseases linked to this target (Open Targets).
- phenylalanine measurement · score 0.19
- mathematical ability · score 0.16
- Barrett's esophagus · score 0.06
- pachyonychia congenita · score 0.04
- BMI-adjusted waist circumference · score 0.04
- esophageal adenocarcinoma · score 0.04
- hepatocellular carcinoma · score 0.03
- hypertrophic cardiomyopathy · score 0.02
- DNA methylation · score 0.02
- plasma protease C1 inhibitor measurement · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75387-F1 | alphafold | PREDICTED | 79.38 | — |
Amino-acid sequence (559 residues)
MAPTLQQAYR RRWWMACTAV LENLFFSAVL LGWGSLLIIL KNEGFYSSTC PAESSTNTTQ DEQRRWPGCD QQDEMLNLGF TIGSFVLSAT TLPLGILMDR FGPRPVRLVG SACFTASCTL MALASRDVEA LSPLIFLALS LNGFGGICLT FTSLTLPNMF GNLRSTLMAL MIGSYASSAI TFPGIKLIYD AGVAFVVIMF TWSGLACLIF LNCTLNWPIE AFPAPEEVNY TKKIKLSGLA LDHKVTGDLF YTHVTTMGQR LSQKAPSLED GSDAFMSPQD VRGTSENLPE RSVPLRKSLC SPTFLWSLLT MGMTQLRIIF YMAAVNKMLE YLVTGGQEHE TNEQQQKVAE TVGFYSSVFG AMQLLCLLTC PLIGYIMDWR IKDCVDAPTQ GTVLGDARDG VATKSIRPRY CKIQKLTNAI SAFTLTNLLL VGFGITCLIN NLHLQFVTFV LHTIVRGFFH SACGSLYAAV FPSNHFGTLT GLQSLISAVF ALLQQPLFMA MVGPLKGEPF WVNLGLLLFS LLGFLLPSYL FYYRARLQQE YAANGMGPLK VLSGSEVTA
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