Citrate synthase, mitochondrial (CS)

About Citrate synthase, mitochondrial

Citrate synthase, mitochondrial (CS) is a protein from Homo sapiens identified by UniProt accession O75390, 466 residues long. MolForge cross-references it against 0 known binders and 387 disease associations.

Target properties

Protein name	Citrate synthase, mitochondrial
UniProt accession	O75390
Gene	CS
Organism	Homo sapiens
Length	466 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (387)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.38
neuroinflammatory disorder · score 0.25
body height · score 0.20
appendicular lean mass · score 0.15
psoriasis · score 0.15
vital capacity · score 0.14
body weight · score 0.10
deafness · score 0.10
autosomal recessive nonsyndromic hearing loss 1B · score 0.08
BMI-adjusted waist circumference · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75390-F1	alphafold	PREDICTED	94.03	—

Amino-acid sequence (466 residues)

MALLTAAARL LGTKNASCLV LAARHASASS TNLKDILADL IPKEQARIKT FRQQHGKTVV GQITVDMMYG GMRGMKGLVY ETSVLDPDEG IRFRGFSIPE CQKLLPKAKG GEEPLPEGLF WLLVTGHIPT EEQVSWLSKE WAKRAALPSH VVTMLDNFPT NLHPMSQLSA AVTALNSESN FARAYAQGIS RTKYWELIYE DSMDLIAKLP CVAAKIYRNL YREGSGIGAI DSNLDWSHNF TNMLGYTDHQ FTELTRLYLT IHSDHEGGNV SAHTSHLVGS ALSDPYLSFA AAMNGLAGPL HGLANQEVLV WLTQLQKEVG KDVSDEKLRD YIWNTLNSGR VVPGYGHAVL RKTDPRYTCQ REFALKHLPN DPMFKLVAQL YKIVPNVLLE QGKAKNPWPN VDAHSGVLLQ YYGMTEMNYY TVLFGVSRAL GVLAQLIWSR ALGFPLERPK SMSTEGLMKF VDSKSG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards