Large ribosomal subunit protein bL33m (MRPL33)

About Large ribosomal subunit protein bL33m

Large ribosomal subunit protein bL33m (MRPL33) is a protein from Homo sapiens identified by UniProt accession O75394, 65 residues long. MolForge cross-references it against 0 known binders and 58 disease associations.

Target properties

Protein name	Large ribosomal subunit protein bL33m
UniProt accession	O75394
Gene	MRPL33
Organism	Homo sapiens
Length	65 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (58)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.50
Alzheimer disease · score 0.33
Parkinson disease · score 0.33
multiple sclerosis · score 0.33
lysosomal storage disease · score 0.33
hemoglobin measurement · score 0.28
hematocrit · score 0.26
schizophrenia · score 0.23
blood urea nitrogen measurement · score 0.20
body mass index · score 0.20

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75394-F1	alphafold	PREDICTED	91.28	—

Amino-acid sequence (65 residues)

MFLSAVFFAK SKSKNILVRM VSEAGTGFCF NTKRNRLREK LTLLHYDPVV KQRVLFVEKK KIRSL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards