Vesicle-trafficking protein SEC22b (SEC22B)

About Vesicle-trafficking protein SEC22b

Vesicle-trafficking protein SEC22b (SEC22B) is a protein from Homo sapiens identified by UniProt accession O75396, 215 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.

Target properties

Protein name	Vesicle-trafficking protein SEC22b
UniProt accession	O75396
Gene	SEC22B
Organism	Homo sapiens
Length	215 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (31)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.19
eosinophil percentage of leukocytes · score 0.03
infection · score 0.03
infect · score 0.03
metabolite measurement · score 0.03
cancer · score 0.01
neoplasm · score 0.01
parasitic infection · score 0.01
Mantle cell lymphoma · score 0.01
ovarian cancer · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75396-F1	alphafold	PREDICTED	83.49	—

Amino-acid sequence (215 residues)

MVLLTMIARV ADGLPLAASM QEDEQSGRDL QQYQSQAKQL FRKLNEQSPT RCTLEAGAMT FHYIIEQGVC YLVLCEAAFP KKLAFAYLED LHSEFDEQHG KKVPTVSRPY SFIEFDTFIQ KTKKLYIDSR ARRNLGSINT ELQDVQRIMV ANIEEVLQRG EALSALDSKA NNLSSLSKKY RQDAKYLNMR STYAKLAAVA VFFIMLIVYV RFWWL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards