About Deformed epidermal autoregulatory factor 1 homolog
Deformed epidermal autoregulatory factor 1 homolog (DEAF1) is a protein
from Homo sapiens identified by UniProt accession
O75398, 565 residues long.
MolForge cross-references it against 0 known binders and
95 disease associations.
Target properties
| Protein name | Deformed epidermal autoregulatory factor 1 homolog |
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| UniProt accession | O75398 |
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| Gene | DEAF1 |
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| Organism | Homo sapiens |
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| Length | 565 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (95)
Diseases linked to this target (Open Targets).
- intellectual disability, autosomal dominant 24 · score 0.73
- intellectual disability-epilepsy-extrapyramidal syndrome · score 0.67
- intellectual developmental disorder with paroxysmal dyskinesia or seizures · score 0.54
- Intellectual disability · score 0.53
- genetic disorder · score 0.47
- autosomal dominant non-syndromic intellectual disability · score 0.44
- Neurodevelopmental delay · score 0.41
- autism spectrum disorder · score 0.36
- body height · score 0.11
- prostate carcinoma · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75398-F1 | alphafold | PREDICTED | 60.44 | — |
Amino-acid sequence (565 residues)
MEDSDSAAKQ LGLAEAAAVA AAAAVAAAAA AAAGGEAEEP VLSRDEDSEE DADSEAERET PRVTAVAVMA AEPGHMDMGA EALPGPDEAA AAAAFAEVTT VTVANVGAAA DNVFTTSVAN AASISGHVLS GRTALQIGDS LNTEKATLIV VHTDGSIVET TGLKGPAAPL TPGPQSPPTP LAPGQEKGGT KYNWDPSVYD SELPVRCRNI SGTLYKNRLG SGGRGRCIKQ GENWYSPTEF EAMAGRASSK DWKRSIRYAG RPLQCLIQDG ILNPHAASCT CAACCDDMTL SGPVRLFVPY KRRKKENELP TTPVKKDSPK NITLLPATAA TTFTVTPSGQ ITTSGALTFD RASTVEATAV ISESPAQGDV FAGATVQEAS VQPPCRASHP EPHYPGYQDS CQIAPFPEAA LPTSHPKIVL TSLPALAVPP PTPTKAAPPA LVNGLELSEP RSWLYLEEMV NSLLNTAQQL KTLFEQAKHA STYREAATNQ AKIHADAERK EQSCVNCGRE AMSECTGCHK VNYCSTFCQR KDWKDHQHIC GQSAAVTVQA DEVHVAESVM EKVTV
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