Huntingtin-interacting protein M (H2AP)

About Huntingtin-interacting protein M

Huntingtin-interacting protein M (H2AP) is a protein from Homo sapiens identified by UniProt accession O75409, 117 residues long. MolForge cross-references it against 0 known binders and 8 disease associations.

Target properties

Protein name	Huntingtin-interacting protein M
UniProt accession	O75409
Gene	H2AP
Organism	Homo sapiens
Length	117 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (8)

Diseases linked to this target (Open Targets).

Short stature · score 0.33
entropion · score 0.05
Trichiasis · score 0.05
vein disorder · score 0.05
lymphatic system disease · score 0.05
Inguinal hernia · score 0.05
Hernia · score 0.05
Varicose veins · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75409-F1	alphafold	PREDICTED	66.47	—

Amino-acid sequence (117 residues)

MSEKKNCKNS STNNNQTQDP SRNELQVPRS FVDRVVQDER DVQSQSSSTI NTLLTLLDCL ADYIMERVGL EASNNGSMRN TSQDREREVD NNREPHSAES DVTRFLFDEM PKSRKND

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards