About Transforming acidic coiled-coil-containing protein 1
Transforming acidic coiled-coil-containing protein 1 (TACC1) is a protein
from Homo sapiens identified by UniProt accession
O75410, 805 residues long.
MolForge cross-references it against 0 known binders and
71 disease associations.
Target properties
| Protein name | Transforming acidic coiled-coil-containing protein 1 |
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| UniProt accession | O75410 |
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| Gene | TACC1 |
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| Organism | Homo sapiens |
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| Length | 805 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (71)
Diseases linked to this target (Open Targets).
- hair color · score 0.37
- prostate carcinoma · score 0.28
- cortical thickness · score 0.27
- hair colour measurement · score 0.27
- brain measurement · score 0.27
- cortical surface area measurement · score 0.25
- mean platelet volume · score 0.18
- Seizure · score 0.15
- neurodegenerative disease · score 0.12
- head and neck squamous cell carcinoma · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75410-F1 | alphafold | PREDICTED | 56.44 | — |
Amino-acid sequence (805 residues)
MAFSPWQILS PVQWAKWTWS AVRGGAAGED EAGGPEGDPE EEDSQAETKS LSFSSDSEGN FETPEAETPI RSPFKESCDP SLGLAGPGAK SQESQEADEQ LVAEVVEKCS SKTCSKPSEN EVPQQAIDSH SVKNFREEPE HDFSKISIVR PFSIETKDST DISAVLGTKA AHGCVTAVSG KALPSSPPDA LQDEAMTEGS MGVTLEASAE ADLKAGNSCP ELVPSRRSKL RKPKPVPLRK KAIGGEFSDT NAAVEGTPLP KASYHFSPEE LDENTSPLLG DARFQKSPPD LKETPGTLSS DTNDSGVELG EESRSSPLKL EFDFTEDTGN IEARKALPRK LGRKLGSTLT PKIQKDGISK SAGLEQPTDP VARDGPLSQT SSKPDPSQWE SPSFNPFGSH SVLQNSPPLS SEGSYHFDPD NFDESMDPFK PTTTLTSSDF CSPTGNHVNE ILESPKKAKS RLITSGCKVK KHETQSLALD ACSRDEGAVI SQISDISNRD GHATDEEKLA STSCGQKSAG AEVKGEPEED LEYFECSNVP VSTINHAFSS SEAGIEKETC QKMEEDGSTV LGLLESSAEK APVSVSCGGE SPLDGICLSE SDKTAVLTLI REEIITKEIE ANEWKKKYEE TRQEVLEMRK IVAEYEKTIA QMIEDEQRTS MTSQKSFQQL TMEKEQALAD LNSVERSLSD LFRRYENLKG VLEGFKKNEE ALKKCAQDYL ARVKQEEQRY QALKIHAEEK LDKANEEIAQ VRTKAKAESA ALHAGLRKEQ MKVESLERAL QQKNQEIEEL TKICDELIAK LGKTD
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