About Nucleoside diphosphate kinase 6, mitochondrial
Nucleoside diphosphate kinase 6, mitochondrial (NME6) is a protein
from Homo sapiens identified by UniProt accession
O75414, 186 residues long.
MolForge cross-references it against 0 known binders and
25 disease associations.
Target properties
| Protein name | Nucleoside diphosphate kinase 6, mitochondrial |
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| UniProt accession | O75414 |
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| Gene | NME6 |
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| Organism | Homo sapiens |
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| Length | 186 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (25)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.49
- emotional symptom measurement · score 0.11
- body weight · score 0.08
- systolic blood pressure · score 0.08
- Diuretic use measurement · score 0.05
- BMI-adjusted waist circumference · score 0.05
- Beta blocking agent use measurement · score 0.05
- urate measurement · score 0.04
- BMI-adjusted waist-hip ratio · score 0.04
- hepatocyte growth factor-like protein measurement · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75414-F1 | alphafold | PREDICTED | 93.15 | — |
Amino-acid sequence (186 residues)
MASILRSPQA LQLTLALIKP DAVAHPLILE AVHQQILSNK FLIVRMRELL WRKEDCQRFY REHEGRFFYQ RLVEFMASGP IRAYILAHKD AIQLWRTLMG PTRVFRARHV APDSIRGSFG LTDTRNTTHG SDSVVSASRE IAAFFPDFSE QRWYEEEEPQ LRCGPVCYSP EGGVHYVAGT GGLGPA
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