About Cell division control protein 45 homolog
Cell division control protein 45 homolog (CDC45) is a protein
from Homo sapiens identified by UniProt accession
O75419, 566 residues long.
MolForge cross-references it against 0 known binders and
110 disease associations.
Target properties
| Protein name | Cell division control protein 45 homolog |
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| UniProt accession | O75419 |
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| Gene | CDC45 |
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| Organism | Homo sapiens |
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| Length | 566 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (110)
Diseases linked to this target (Open Targets).
- Ear-patella-short stature syndrome · score 0.80
- endometrial cancer · score 0.27
- glioblastoma multiforme · score 0.26
- lung adenocarcinoma · score 0.24
- breast adenocarcinoma · score 0.23
- genetic disorder · score 0.19
- esophageal cancer · score 0.17
- Microcephaly · score 0.11
- androgen insensitivity syndrome · score 0.11
- hepatocellular carcinoma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75419-F1 | alphafold | PREDICTED | 92.54 | — |
Amino-acid sequence (566 residues)
MFVSDFRKEF YEVVQSQRVL LFVASDVDAL CACKILQALF QCDHVQYTLV PVSGWQELET AFLEHKEQFH YFILINCGAN VDLLDILQPD EDTIFFVCDT HRPVNVVNVY NDTQIKLLIK QDDDLEVPAY EDIFRDEEED EEHSGNDSDG SEPSEKRTRL EEEIVEQTMR RRQRREWEAR RRDILFDYEQ YEYHGTSSAM VMFELAWMLS KDLNDMLWWA IVGLTDQWVQ DKITQMKYVT DVGVLQRHVS RHNHRNEDEE NTLSVDCTRI SFEYDLRLVL YQHWSLHDSL CNTSYTAARF KLWSVHGQKR LQEFLADMGL PLKQVKQKFQ AMDISLKENL REMIEESANK FGMKDMRVQT FSIHFGFKHK FLASDVVFAT MSLMESPEKD GSGTDHFIQA LDSLSRSNLD KLYHGLELAK KQLRATQQTI ASCLCTNLVI SQGPFLYCSL MEGTPDVMLF SRPASLSLLS KHLLKSFVCS TKNRRCKLLP LVMAAPLSME HGTVTVVGIP PETDSSDRKN FFGRAFEKAA ESTSSRMLHN HFDLSVIELK AEDRSKFLDA LISLLS
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