About F-box only protein 24
F-box only protein 24 (FBXO24) is a protein
from Homo sapiens identified by UniProt accession
O75426, 580 residues long.
MolForge cross-references it against 0 known binders and
139 disease associations.
Target properties
| Protein name | F-box only protein 24 |
|---|
| UniProt accession | O75426 |
|---|
| Gene | FBXO24 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 580 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (139)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.18
- neuroimaging measurement · score 0.11
- azoospermia · score 0.10
- reticulocyte count · score 0.10
- brain volume measurement · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.09
- mean reticulocyte volume · score 0.08
- partial chromosome Y deletion · score 0.08
- spermatogenic failure 65 · score 0.07
- reticulocyte measurement · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75426-F1 | alphafold | PREDICTED | 76.76 | — |
Amino-acid sequence (580 residues)
MGEKAVPLLR RRRVKRSCPS CGSELGVEEK RGKGNPISIQ LFPPELVEHI ISFLPVRDLV ALGQTCRYFH EVCDGEGVWR RICRRLSPRL QDQGSGVRPW KRAAILNYTK GLYFQAFGGR RRCLSKSVAP LLAHGYRRFL PTKDHVFILD YVGTLFFLKN ALVSTLGQMQ WKRACRYVVL CRGAKDFASD PRCDTVYRKY LYVLATREPQ EVVGTTSSRA CDCVEVYLQS SGQRVFKMTF HHSMTFKQIV LVGQETQRAL LLLTEEGKIY SLVVNETQLD QPRSYTVQLA LRKVSHYLPH LRVACMTSNQ SSTLYVTDQG GVYFEVHTPG VYRDLFGTLQ AFDPLDQQMP LALSLPAKIL FCALGYNHLG LVDEFGRIFM QGNNRYGQLG TGDKMDRGEP TQVCYLQRPI TLWCGLNHSL VLSQSSEFSK ELLGCGCGAG GRLPGWPKGS ASFVKLQVKV PLCACALCAT RECLYILSSH DIEQHAPYRH LPASRVVGTP EPSLGARAPQ DPGGMAQACE EYLSQIHSCQ TLQDRTEKMK EIVGWMPLMA AQKDFFWEAL DMLQRAEGGG GGVGPPAPET
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