About Leucine-rich repeat and calponin homology domain-containing protein 4
Leucine-rich repeat and calponin homology domain-containing protein 4 (LRCH4) is a protein
from Homo sapiens identified by UniProt accession
O75427, 683 residues long.
MolForge cross-references it against 0 known binders and
23 disease associations.
Target properties
| Protein name | Leucine-rich repeat and calponin homology domain-containing protein 4 |
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| UniProt accession | O75427 |
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| Gene | LRCH4 |
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| Organism | Homo sapiens |
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| Length | 683 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (23)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.16
- neuroimaging measurement · score 0.15
- reticulocyte count · score 0.15
- brain measurement · score 0.12
- brain volume measurement · score 0.12
- mean platelet volume · score 0.10
- mean reticulocyte volume · score 0.10
- macula measurement · score 0.08
- bowel opening frequency · score 0.08
- mean corpuscular hemoglobin · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75427-F1 | alphafold | PREDICTED | 64.19 | — |
Amino-acid sequence (683 residues)
MAAAVAAPLA AGGEEAAATT SVPGSPGLPG RRSAERALEE AVATGTLNLS NRRLKHFPRG AARSYDLSDI TQADLSRNRF PEVPEAACQL VSLEGLSLYH NCLRCLNPAL GNLTALTYLN LSRNQLSLLP PYICQLPLRV LIVSNNKLGA LPPDIGTLGS LRQLDVSSNE LQSLPSELCG LSSLRDLNVR RNQLSTLPEE LGDLPLVRLD FSCNRVSRIP VSFCRLRHLQ VILLDSNPLQ SPPAQVCLKG KLHIFKYLST EAGQRGSALG DLAPSRPPSF SPCPAEDLFP GHRYDGGLDS GFHSVDSGSK RWSGNESTDE FSELSFRISE LAREPRGPRE RKEDGSADGD PVQIDFIDSH VPGEDEERGT VEEQRPPELS PGAGDRERAP SSRREEPAGE ERRRPDTLQL WQERERRQQQ QSGAWGAPRK DSLLKPGLRA VVGGAAAVST QAMHNGSPKS SASQAGAAAG QGAPAPAPAS QEPLPIAGPA TAPAPRPLGS IQRPNSFLFR SSSQSGSGPS SPDSVLRPRR YPQVPDEKDL MTQLRQVLES RLQRPLPEDL AEALASGVIL CQLANQLRPR SVPFIHVPSP AVPKLSALKA RKNVESFLEA CRKMGVPEAD LCSPSDLLQG TARGLRTALE AVKRVGGKAL PPLWPPSGLG GFVVFYVVLM LLLYVTYTRL LGS
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