About Metaxin-2
Metaxin-2 (MTX2) is a protein
from Homo sapiens identified by UniProt accession
O75431, 263 residues long.
MolForge cross-references it against 0 known binders and
71 disease associations.
Target properties
| Protein name | Metaxin-2 |
|---|
| UniProt accession | O75431 |
|---|
| Gene | MTX2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 263 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (71)
Diseases linked to this target (Open Targets).
- mandibuloacral dysplasia progeroid syndrome · score 0.67
- mandibuloacral dysplasia · score 0.50
- lipodystrophy · score 0.50
- Lipodystrophy · score 0.50
- skeletal dysplasia · score 0.37
- Skeletal dysplasia · score 0.37
- hypertension · score 0.35
- Micrognathia · score 0.33
- Postnatal growth retardation · score 0.33
- Dental crowding · score 0.33
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75431-F1 | alphafold | PREDICTED | 92.15 | — |
Amino-acid sequence (263 residues)
MSLVAEAFVS QIAAAEPWPE NATLYQQLKG EQILLSDNAA SLAVQAFLQM CNLPIKVVCR ANAEYMSPSG KVPFIHVGNQ VVSELGPIVQ FVKAKGHSLS DGLEEVQKAE MKAYMELVNN MLLTAELYLQ WCDEATVGEI THARYGSPYP WPLNHILAYQ KQWEVKRKMK AIGWGKKTLD QVLEDVDQCC QALSQRLGTQ PYFFNKQPTE LDALVFGHLY TILTTQLTND ELSEKVKNYS NLLAFCRRIE QHYFEDRGKG RLS
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