NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (NDUFB1)

Homo sapiens — UniProt O75438

Gene: NDUFB1Homo sapiensSwissProt reviewed

About NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 (NDUFB1) is a protein from Homo sapiens identified by UniProt accession O75438, 58 residues long. MolForge cross-references it against 0 known binders and 228 disease associations.

Target properties

Protein nameNADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1
UniProt accessionO75438
GeneNDUFB1
OrganismHomo sapiens
Length58 residues
Molecular weight—
EC numbers—
Target classUNCLASSIFIED
Subcellular location—
Keywords—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tierMEDIUM
Druggability score—
Pocket score—
Max clinical phase—

Disease associations (228)

Diseases linked to this target (Open Targets).

  • type 2 diabetes mellitus · score 0.61
  • diabetes mellitus · score 0.60
  • polycystic ovary syndrome · score 0.60
  • type 1 diabetes mellitus · score 0.58
  • gestational diabetes · score 0.58
  • obesity · score 0.57
  • prediabetes syndrome · score 0.56
  • schizophrenia · score 0.55
  • insulin resistance · score 0.55
  • metabolic syndrome · score 0.53

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

StructureSourceMethodMean pLDDTResolution (Å)
AF-O75438-F1alphafoldPREDICTED91.28—

Amino-acid sequence (58 residues)

MVNLLQIVRD HWVHVLVPMG FVIGCYLDRK SDERLTAFRN KSMLFKRELQ PSEEVTWK

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Quick facts

UniProtO75438
GeneNDUFB1
OrganismHomo sapiens
Length58
Binders0
Diseases228
View on UniProt