About Mitochondrial-processing peptidase subunit beta
Mitochondrial-processing peptidase subunit beta (PMPCB) is a protein
from Homo sapiens identified by UniProt accession
O75439, 489 residues long.
MolForge cross-references it against 0 known binders and
21 disease associations.
Target properties
| Protein name | Mitochondrial-processing peptidase subunit beta |
|---|
| UniProt accession | O75439 |
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| Gene | PMPCB |
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| Organism | Homo sapiens |
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| Length | 489 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (21)
Diseases linked to this target (Open Targets).
- multiple mitochondrial dysfunctions syndrome 6 · score 0.80
- neurodegenerative disease · score 0.53
- genetic disorder · score 0.38
- urate measurement · score 0.11
- bone density · score 0.11
- type 2 diabetes mellitus · score 0.09
- lower face morphology measurement · score 0.03
- lymphocyte count · score 0.02
- neoplasm · score 0.02
- hepatocellular carcinoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75439-F1 | alphafold | PREDICTED | 87.23 | — |
Amino-acid sequence (489 residues)
MAAAAARVVL SSAARRRLWG FSESLLIRGA AGRSLYFGEN RLRSTQAATQ VVLNVPETRV TCLESGLRVA SEDSGLSTCT VGLWIDAGSR YENEKNNGTA HFLEHMAFKG TKKRSQLDLE LEIENMGAHL NAYTSREQTV YYAKAFSKDL PRAVEILADI IQNSTLGEAE IERERGVILR EMQEVETNLQ EVVFDYLHAT AYQNTALGRT ILGPTENIKS ISRKDLVDYI TTHYKGPRIV LAAAGGVSHD ELLDLAKFHF GDSLCTHKGE IPALPPCKFT GSEIRVRDDK MPLAHLAIAV EAVGWAHPDT ICLMVANTLI GNWDRSFGGG MNLSSKLAQL TCHGNLCHSF QSFNTSYTDT GLWGLYMVCE SSTVADMLHV VQKEWMRLCT SVTESEVARA RNLLKTNMLL QLDGSTPICE DIGRQMLCYN RRIPIPELEA RIDAVNAETI REVCTKYIYN RSPAIAAVGP IKQLPDFKQI RSNMCWLRD
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