Transcription factor Maf (MAF)

About Transcription factor Maf

Transcription factor Maf (MAF) is a protein from Homo sapiens identified by UniProt accession O75444, 373 residues long. MolForge cross-references it against 0 known binders and 517 disease associations.

Target properties

Protein name	Transcription factor Maf
UniProt accession	O75444
Gene	MAF
Organism	Homo sapiens
Length	373 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (517)

Diseases linked to this target (Open Targets).

Aymé-Gripp syndrome · score 0.79
early-onset non-syndromic cataract · score 0.56
urate measurement · score 0.45
alkaline phosphatase measurement · score 0.45
uric acid measurement · score 0.44
vitamin D measurement · score 0.44
platelet count · score 0.44
sex hormone-binding globulin measurement · score 0.42
bilirubin measurement · score 0.40
eosinophil count · score 0.40

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75444-F1	alphafold	PREDICTED	59.34	—

Amino-acid sequence (373 residues)

MASELAMSNS DLPTSPLAME YVNDFDLMKF EVKKEPVETD RIISQCGRLI AGGSLSSTPM STPCSSVPPS PSFSAPSPGS GSEQKAHLED YYWMTGYPQQ LNPEALGFSP EDAVEALISN SHQLQGGFDG YARGAQQLAA AAGAGAGASL GGSGEEMGPA AAVVSAVIAA AAAQSGAGPH YHHHHHHAAG HHHHPTAGAP GAAGSAAASA GGAGGAGGGG PASAGGGGGG GGGGGGGGAA GAGGALHPHH AAGGLHFDDR FSDEQLVTMS VRELNRQLRG VSKEEVIRLK QKRRTLKNRG YAQSCRFKRV QQRHVLESEK NQLLQQVDHL KQEISRLVRE RDAYKEKYEK LVSSGFRENG SSSDNPSSPE FFM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards