About Histone deacetylase complex subunit SAP30
Histone deacetylase complex subunit SAP30 (SAP30) is a protein
from Homo sapiens identified by UniProt accession
O75446, 220 residues long.
MolForge cross-references it against 0 known binders and
78 disease associations.
Target properties
| Protein name | Histone deacetylase complex subunit SAP30 |
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| UniProt accession | O75446 |
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| Gene | SAP30 |
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| Organism | Homo sapiens |
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| Length | 220 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (78)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- neoplasm · score 0.09
- acute myeloid leukemia · score 0.07
- breast cancer · score 0.07
- neuroblastoma · score 0.07
- chin morphology measurement · score 0.06
- MODY · score 0.05
- hemoglobin D disease · score 0.05
- triple-negative breast cancer · score 0.05
- heel bone mineral density · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75446-F1 | alphafold | PREDICTED | 67.33 | — |
Amino-acid sequence (220 residues)
MNGFTPDEMS RGGDAAAAVA AVVAAAAAAA SAGNGTGAGT GAEVPGAGAV SAAGPPGAAG PGPGQLCCLR EDGERCGRAA GNASFSKRIQ KSISQKKVKI ELDKSARHLY ICDYHKNLIQ SVRNRRKRKG SDDDGGDSPV QDIDTPEVDL YQLQVNTLRR YKRHFKLPTR PGLNKAQLVE IVGCHFRSIP VNEKDTLTYF IYSVKNDKNK SDLKVDSGVH
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