About Katanin p60 ATPase-containing subunit A1
Katanin p60 ATPase-containing subunit A1 (KATNA1) is a protein
from Homo sapiens identified by UniProt accession
O75449, 491 residues long.
MolForge cross-references it against 0 known binders and
52 disease associations.
Target properties
| Protein name | Katanin p60 ATPase-containing subunit A1 |
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| UniProt accession | O75449 |
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| Gene | KATNA1 |
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| Organism | Homo sapiens |
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| Length | 491 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (52)
Diseases linked to this target (Open Targets).
- refractive error measurement · score 0.06
- X-linked non-syndromic intellectual disability · score 0.06
- 46,XX testicular disorder of sex development · score 0.06
- benign prostatic hyperplasia · score 0.06
- familial male-limited precocious puberty · score 0.06
- X-linked intellectual disability-macrocephaly-macroorchidism syndrome · score 0.06
- 46,XY complete gonadal dysgenesis · score 0.05
- isolated congenital hypogonadotropic hypogonadism · score 0.05
- Testicular regression syndrome · score 0.05
- cryptorchidism · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75449-F1 | alphafold | PREDICTED | 75.03 | — |
Amino-acid sequence (491 residues)
MSLLMISENV KLAREYALLG NYDSAMVYYQ GVLDQMNKYL YSVKDTYLQQ KWQQVWQEIN VEAKHVKDIM KTLESFKLDS TPLKAAQHDL PASEGEVWSM PVPVERRPSP GPRKRQSSQY SDPKSHGNRP STTVRVHRSS AQNVHNDRGK AVRCREKKEQ NKGREEKNKS PAAVTEPETN KFDSTGYDKD LVEALERDII SQNPNVRWDD IADLVEAKKL LKEAVVLPMW MPEFFKGIRR PWKGVLMVGP PGTGKTLLAK AVATECKTTF FNVSSSTLTS KYRGESEKLV RLLFEMARFY SPATIFIDEI DSICSRRGTS EEHEASRRVK AELLVQMDGV GGTSENDDPS KMVMVLAATN FPWDIDEALR RRLEKRIYIP LPSAKGREEL LRISLRELEL ADDVDLASIA ENMEGYSGAD ITNVCRDASL MAMRRRIEGL TPEEIRNLSK EEMHMPTTME DFEMALKKVS KSVSAADIER YEKWIFEFGS C
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