About Retinol dehydrogenase 16
Retinol dehydrogenase 16 (RDH16) is a protein
from Homo sapiens identified by UniProt accession
O75452, 317 residues long.
MolForge cross-references it against 0 known binders and
70 disease associations.
Target properties
| Protein name | Retinol dehydrogenase 16 |
|---|
| UniProt accession | O75452 |
|---|
| Gene | RDH16 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 317 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (70)
Diseases linked to this target (Open Targets).
- eosinophil percentage of leukocytes · score 0.19
- testosterone measurement · score 0.11
- vital capacity · score 0.11
- breast adenocarcinoma · score 0.11
- age at menarche · score 0.09
- Red cell distribution width · score 0.08
- allergic disease · score 0.07
- heel bone mineral density · score 0.07
- thrombocythemia 2 · score 0.06
- hepatocellular carcinoma · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75452-F1 | alphafold | PREDICTED | 96.39 | — |
Amino-acid sequence (317 residues)
MWLYLAVFVG LYYLLHWYRE RQVLSHLRDK YVFITGCDSG FGKLLARQLD ARGLRVLAAC LTEKGAEQLR GQTSDRLETV TLDVTKTESV AAAAQWVKEC VRDKGLWGLV NNAGISLPTA PNELLTKQDF VTILDVNLLG VIDVTLSLLP LVRRARGRVV NVSSVMGRVS LFGGGYCISK YGVEAFSDSL RRELSYFGVK VAMIEPGYFK TAVTSKERFL KSFLEIWDRS SPEVKEAYGE KFVADYKKSA EQMEQKCTQD LSLVTNCMEH ALIACHPRTR YSAGWDAKLL YLPMSYMPTF LVDAIMYWVS PSPAKAL
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