About Transcription factor E2F6
Transcription factor E2F6 (E2F6) is a protein
from Homo sapiens identified by UniProt accession
O75461, 281 residues long.
MolForge cross-references it against 0 known binders and
150 disease associations.
Target properties
| Protein name | Transcription factor E2F6 |
|---|
| UniProt accession | O75461 |
|---|
| Gene | E2F6 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 281 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (150)
Diseases linked to this target (Open Targets).
- electrocardiography · score 0.38
- neurodegenerative disease · score 0.36
- coronary artery disease · score 0.26
- Emotional lability · score 0.13
- cortical thickness · score 0.09
- brain measurement · score 0.09
- creatinine measurement · score 0.09
- cystatin C measurement · score 0.09
- glioblastoma multiforme · score 0.08
- uterine fibroid · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75461-F1 | alphafold | PREDICTED | 71.14 | — |
Amino-acid sequence (281 residues)
MSQQRPARKL PSLLLDPTEE TVRRRCRDPI NVEGLLPSKI RINLEDNVQY VSMRKALKVK RPRFDVSLVY LTRKFMDLVR SAPGGILDLN KVATKLGVRK RRVYDITNVL DGIDLVEKKS KNHIRWIGSD LSNFGAVPQQ KKLQEELSDL SAMEDALDEL IKDCAQQLFE LTDDKENERL AYVTYQDIHS IQAFHEQIVI AVKAPAETRL DVPAPREDSI TVHIRSTNGP IDVYLCEVEQ GQTSNKRSEG VGTSSSESTH PEGPEEEENP QQSEELLEVS N
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