Cytokine receptor-like factor 1 (CRLF1)

About Cytokine receptor-like factor 1

Cytokine receptor-like factor 1 (CRLF1) is a protein from Homo sapiens identified by UniProt accession O75462, 422 residues long. MolForge cross-references it against 0 known binders and 78 disease associations.

Target properties

Protein name	Cytokine receptor-like factor 1
UniProt accession	O75462
Gene	CRLF1
Organism	Homo sapiens
Length	422 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (78)

Diseases linked to this target (Open Targets).

Cold-induced sweating syndrome 1 · score 0.81
cold-induced sweating syndrome · score 0.55
genetic disorder · score 0.41
Crisponi syndrome · score 0.37
Achalasia · score 0.37
cone-rod dystrophy 12 · score 0.27
blood protein measurement · score 0.26
lung adenocarcinoma · score 0.22
dental caries · score 0.15
dentures · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75462-F1	alphafold	PREDICTED	80.25	—

Amino-acid sequence (422 residues)

MPAGRRGPAA QSARRPPPLL PLLLLLCVLG APRAGSGAHT AVISPQDPTL LIGSSLLATC SVHGDPPGAT AEGLYWTLNG RRLPPELSRV LNASTLALAL ANLNGSRQRS GDNLVCHARD GSILAGSCLY VGLPPEKPVN ISCWSKNMKD LTCRWTPGAH GETFLHTNYS LKYKLRWYGQ DNTCEEYHTV GPHSCHIPKD LALFTPYEIW VEATNRLGSA RSDVLTLDIL DVVTTDPPPD VHVSRVGGLE DQLSVRWVSP PALKDFLFQA KYQIRYRVED SVDWKVVDDV SNQTSCRLAG LKPGTVYFVQ VRCNPFGIYG SKKAGIWSEW SHPTAASTPR SERPGPGGGA CEPRGGEPSS GPVRRELKQF LGWLKKHAYC SNLSFRLYDQ WRAWMQKSHK TRNQDEGILP SGRRGTARGP AR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards