About Nuclear receptor subfamily 1 group I member 2
Nuclear receptor subfamily 1 group I member 2 (NR1I2) is a protein
from Homo sapiens identified by UniProt accession
O75469, 434 residues long.
MolForge cross-references it against 0 known binders and
296 disease associations.
Target properties
| Protein name | Nuclear receptor subfamily 1 group I member 2 |
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| UniProt accession | O75469 |
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| Gene | NR1I2 |
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| Organism | Homo sapiens |
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| Length | 434 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (296)
Diseases linked to this target (Open Targets).
- high density lipoprotein cholesterol measurement · score 0.42
- apolipoprotein A 1 measurement · score 0.39
- total cholesterol measurement · score 0.39
- serum gamma-glutamyl transferase measurement · score 0.38
- low density lipoprotein cholesterol measurement · score 0.31
- body mass index · score 0.27
- adolescent idiopathic scoliosis · score 0.26
- bilirubin measurement · score 0.21
- leukocyte count · score 0.21
- neurodegenerative disease · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75469-F1 | alphafold | PREDICTED | 85.47 | — |
Amino-acid sequence (434 residues)
MEVRPKESWN HADFVHCEDT ESVPGKPSVN ADEEVGGPQI CRVCGDKATG YHFNVMTCEG CKGFFRRAMK RNARLRCPFR KGACEITRKT RRQCQACRLR KCLESGMKKE MIMSDEAVEE RRALIKRKKS ERTGTQPLGV QGLTEEQRMM IRELMDAQMK TFDTTFSHFK NFRLPGVLSS GCELPESLQA PSREEAAKWS QVRKDLCSLK VSLQLRGEDG SVWNYKPPAD SGGKEIFSLL PHMADMSTYM FKGIISFAKV ISYFRDLPIE DQISLLKGAA FELCQLRFNT VFNAETGTWE CGRLSYCLED TAGGFQQLLL EPMLKFHYML KKLQLHEEEY VLMQAISLFS PDRPGVLQHR VVDQLQEQFA ITLKSYIECN RPQPAHRFLF LKIMAMLTEL RSINAQHTQR LLRIQDIHPF ATPLMQELFG ITGS
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