About GSK-3-binding protein FRAT2
GSK-3-binding protein FRAT2 (FRAT2) is a protein
from Homo sapiens identified by UniProt accession
O75474, 233 residues long.
MolForge cross-references it against 0 known binders and
51 disease associations.
Target properties
| Protein name | GSK-3-binding protein FRAT2 |
|---|
| UniProt accession | O75474 |
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| Gene | FRAT2 |
|---|
| Organism | Homo sapiens |
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| Length | 233 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (51)
Diseases linked to this target (Open Targets).
- serum alanine aminotransferase measurement · score 0.32
- neutrophil count · score 0.26
- serum gamma-glutamyl transferase measurement · score 0.22
- monocyte count · score 0.16
- leukocyte count · score 0.15
- HbA1c measurement · score 0.14
- lymphocyte percentage of leukocytes · score 0.13
- grip strength measurement · score 0.13
- monocyte percentage of leukocytes · score 0.12
- eosinophil count · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75474-F1 | alphafold | PREDICTED | 62.13 | — |
Amino-acid sequence (233 residues)
MPCRREEEEE AGEEAEGEEE EDDSFLLLQQ SVTLGSSGEV DRLVAQIGET LQLDAAQDSP ASPCAPPGVP LRAPGPLAAA VPADKARPPA VPLLLPPASA ETVGPAPSGA LRCALGDRGR VRGRAAPYCV AEVAAGPSAL PGPCRRGWLR DAVTSRRLQQ RRWTQAGARA GDDDPHRLLQ QLVLSGNLIK EAVRRLQRAV AAVAATGPAS APGPGGGRSG PDRIALQPSG SLL
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