About PC4 and SFRS1-interacting protein
PC4 and SFRS1-interacting protein (PSIP1) is a protein
from Homo sapiens identified by UniProt accession
O75475, 530 residues long.
MolForge cross-references it against 0 known binders and
277 disease associations.
Target properties
| Protein name | PC4 and SFRS1-interacting protein |
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| UniProt accession | O75475 |
|---|
| Gene | PSIP1 |
|---|
| Organism | Homo sapiens |
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| Length | 530 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (277)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.59
- body fat percentage · score 0.39
- urinary bladder carcinoma · score 0.37
- gastric carcinoma · score 0.37
- Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation · score 0.37
- carcinoma of liver and intrahepatic biliary tract · score 0.37
- Endometrial Endometrioid Adenocarcinoma · score 0.37
- colorectal adenocarcinoma · score 0.37
- fat body mass · score 0.34
- urinary bladder cancer · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75475-F1 | alphafold | PREDICTED | 62.64 | — |
Amino-acid sequence (530 residues)
MTRDFKPGDL IFAKMKGYPH WPARVDEVPD GAVKPPTNKL PIFFFGTHET AFLGPKDIFP YSENKEKYGK PNKRKGFNEG LWEIDNNPKV KFSSQQAATK QSNASSDVEV EEKETSVSKE DTDHEEKASN EDVTKAVDIT TPKAARRGRK RKAEKQVETE EAGVVTTATA SVNLKVSPKR GRPAATEVKI PKPRGRPKMV KQPCPSESDI ITEEDKSKKK GQEEKQPKKQ PKKDEEGQKE EDKPRKEPDK KEGKKEVESK RKNLAKTGVT STSDSEEEGD DQEGEKKRKG GRNFQTAHRR NMLKGQHEKE AADRKRKQEE QMETEQQNKD EGKKPEVKKV EKKRETSMDS RLQRIHAEIK NSLKIDNLDV NRCIEALDEL ASLQVTMQQA QKHTEMITTL KKIRRFKVSQ VIMEKSTMLY NKFKNMFLVG EGDSVITQVL NKSLAEQRQH EEANKTKDQG KKGPNKKLEK EQTGSKTLNG GSDAQDGNQP QHNGESNEDS KDNHEASTKK KPSSEERETE ISLKDSTLDN
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