About Glypican-4
Glypican-4 (GPC4) is a protein
from Homo sapiens identified by UniProt accession
O75487, 556 residues long.
MolForge cross-references it against 0 known binders and
207 disease associations.
Target properties
| Protein name | Glypican-4 |
|---|
| UniProt accession | O75487 |
|---|
| Gene | GPC4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 556 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (207)
Diseases linked to this target (Open Targets).
- Keipert syndrome · score 0.73
- COVID-19 · score 0.54
- neurodegenerative disease · score 0.37
- craniosynostosis · score 0.26
- cutaneous melanoma · score 0.24
- lung adenocarcinoma · score 0.24
- genetic disorder · score 0.19
- breast adenocarcinoma · score 0.16
- head and neck squamous cell carcinoma · score 0.15
- Blackfan-Diamond anemia · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75487-F1 | alphafold | PREDICTED | 83.19 | — |
Amino-acid sequence (556 residues)
MARFGLPALL CTLAVLSAAL LAAELKSKSC SEVRRLYVSK GFNKNDAPLH EINGDHLKIC PQGSTCCSQE MEEKYSLQSK DDFKSVVSEQ CNHLQAVFAS RYKKFDEFFK ELLENAEKSL NDMFVKTYGH LYMQNSELFK DLFVELKRYY VVGNVNLEEM LNDFWARLLE RMFRLVNSQY HFTDEYLECV SKYTEQLKPF GDVPRKLKLQ VTRAFVAART FAQGLAVAGD VVSKVSVVNP TAQCTHALLK MIYCSHCRGL VTVKPCYNYC SNIMRGCLAN QGDLDFEWNN FIDAMLMVAE RLEGPFNIES VMDPIDVKIS DAIMNMQDNS VQVSQKVFQG CGPPKPLPAG RISRSISESA FSARFRPHHP EERPTTAAGT SLDRLVTDVK EKLKQAKKFW SSLPSNVCND ERMAAGNGNE DDCWNGKGKS RYLFAVTGNG LANQGNNPEV QVDTSKPDIL ILRQIMALRV MTSKMKNAYN GNDVDFFDIS DESSGEGSGS GCEYQQCPSE FDYNATDHAG KSANEKADSA GVRPGAQAYL LTVFCILFLV MQREWR
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