About Geminin
Geminin (GMNN) is a protein
from Homo sapiens identified by UniProt accession
O75496, 209 residues long.
MolForge cross-references it against 0 known binders and
207 disease associations.
Target properties
| Protein name | Geminin |
|---|
| UniProt accession | O75496 |
|---|
| Gene | GMNN |
|---|
| Organism | Homo sapiens |
|---|
| Length | 209 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (207)
Diseases linked to this target (Open Targets).
- Ear-patella-short stature syndrome · score 0.69
- Meier-Gorlin syndrome · score 0.45
- neurodegenerative disease · score 0.37
- microcephalic primordial dwarfism · score 0.37
- lysosomal storage disease · score 0.29
- genetic disorder · score 0.17
- body mass index · score 0.12
- neoplasm · score 0.11
- early-onset non-syndromic cataract · score 0.10
- isolated ectopia lentis · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75496-F1 | alphafold | PREDICTED | 69.53 | — |
Amino-acid sequence (209 residues)
MNPSMKQKQE EIKENIKNSS VPRRTLKMIQ PSASGSLVGR ENELSAGLSK RKHRNDHLTS TTSSPGVIVP ESSENKNLGG VTQESFDLMI KENPSSQYWK EVAEKRRKAL YEALKENEKL HKEIEQKDNE IARLKKENKE LAEVAEHVQY MAELIERLNG EPLDNFESLD NQEFDSEEET VEDSLVEDSE IGTCAEGTVS SSTDAKPCI
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