Bis(monoacylglycero)phosphate synthase CLN5 (CLN5)

About Bis(monoacylglycero)phosphate synthase CLN5

Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) is a protein from Homo sapiens identified by UniProt accession O75503, 358 residues long. MolForge cross-references it against 0 known binders and 325 disease associations.

Target properties

Protein name	Bis(monoacylglycero)phosphate synthase CLN5
UniProt accession	O75503
Gene	CLN5
Organism	Homo sapiens
Length	358 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (325)

Diseases linked to this target (Open Targets).

CLN5 disease · score 0.81
neuronal ceroid lipofuscinosis 5 · score 0.81
neuronal ceroid lipofuscinosis · score 0.67
intellectual disability, short stature, facial anomalies, and joint dislocations · score 0.48
genetic disorder · score 0.47
chronotype measurement · score 0.36
Abnormality of metabolism/homeostasis · score 0.34
pontocerebellar hypoplasia type 2 · score 0.27
blood protein measurement · score 0.25
circadian rhythm · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75503-F1	alphafold	PREDICTED	82.29	—

Amino-acid sequence (358 residues)

MAQEVDTAQG AEMRRGAGAA RGRASWCWAL ALLWLAVVPG WSRVSGIPSR RHWPVPYKRF DFRPKPDPYC QAKYTFCPTG SPIPVMEGDD DIEVFRLQAP VWEFKYGDLL GHLKIMHDAI GFRSTLTGKN YTMEWYELFQ LGNCTFPHLR PEMDAPFWCN QGAACFFEGI DDVHWKENGT LVQVATISGN MFNQMAKWVK QDNETGIYYE TWNVKASPEK GAETWFDSYD CSKFVLRTFN KLAEFGAEFK NIETNYTRIF LYSGEPTYLG NETSVFGPTG NKTLGLAIKR FYYPFKPHLP TKEFLLSLLQ IFDAVIVHKQ FYLFYNFEYW FLPMKFPFIK ITYEEIPLPI RNKTLSGL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards