About KH domain-containing, RNA-binding, signal transduction-associated protein 3
KH domain-containing, RNA-binding, signal transduction-associated protein 3 (KHDRBS3) is a protein
from Homo sapiens identified by UniProt accession
O75525, 346 residues long.
MolForge cross-references it against 0 known binders and
94 disease associations.
Target properties
| Protein name | KH domain-containing, RNA-binding, signal transduction-associated protein 3 |
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| UniProt accession | O75525 |
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| Gene | KHDRBS3 |
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| Organism | Homo sapiens |
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| Length | 346 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (94)
Diseases linked to this target (Open Targets).
- protein measurement · score 0.36
- mathematical ability · score 0.30
- adolescent idiopathic scoliosis · score 0.27
- neurofibrillary tangles measurement · score 0.25
- self reported educational attainment · score 0.24
- gut microbiome measurement · score 0.23
- response to serotonin-norephinephrine reuptake inhibitor · score 0.22
- esophageal disease · score 0.22
- chronotype measurement · score 0.20
- hemoglobin measurement · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75525-F1 | alphafold | PREDICTED | 68.88 | — |
Amino-acid sequence (346 residues)
MEEKYLPELM AEKDSLDPSF THALRLVNQE IEKFQKGEGK DEEKYIDVVI NKNMKLGQKV LIPVKQFPKF NFVGKLLGPR GNSLKRLQEE TLTKMSILGK GSMRDKAKEE ELRKSGEAKY FHLNDDLHVL IEVFAPPAEA YARMGHALEE IKKFLIPDYN DEIRQAQLQE LTYLNGGSEN ADVPVVRGKP TLRTRGVPAP AITRGRGGVT ARPVGVVVPR GTPTPRGVLS TRGPVSRGRG LLTPRARGVP PTGYRPPPPP PTQETYGEYD YDDGYGTAYD EQSYDSYDNS YSTPAQSGAD YYDYGHGLSE ETYDSYGQEE WTNSRHKAPS ARTAKGVYRD QPYGRY
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