RNA-binding motif protein, X-linked-like-2 (RBMXL2)

About RNA-binding motif protein, X-linked-like-2

RNA-binding motif protein, X-linked-like-2 (RBMXL2) is a protein from Homo sapiens identified by UniProt accession O75526, 392 residues long. MolForge cross-references it against 0 known binders and 91 disease associations.

Target properties

Protein name	RNA-binding motif protein, X-linked-like-2
UniProt accession	O75526
Gene	RBMXL2
Organism	Homo sapiens
Length	392 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (91)

Diseases linked to this target (Open Targets).

azoospermia · score 0.09
male infertility with teratozoospermia due to single gene mutation · score 0.07
partial chromosome Y deletion · score 0.07
spermatogenic failure 25 · score 0.06
spermatogenic failures 50 · score 0.06
congenital bilateral absence of vas deferens · score 0.06
spermatogenic failure, X-linked, 2 · score 0.06
isochromosomy Yp · score 0.06
spinocerebellar ataxia type 32 · score 0.06
spermatogenic failure 63 · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75526-F1	alphafold	PREDICTED	54.59	—

Amino-acid sequence (392 residues)

MVEADRPGKL FIGGLNLETD EKALEAEFGK YGRIVEVLLM KDRETNKSRG FAFVTFESPA DAKAAARDMN GKSLDGKAIK VAQATKPAFE SSRRGPPPPR SRGRPRFLRG TRGGGGGPRR SPSRGGPDDD GGYTADFDLR PSRAPMPMKR GPPPRRVGPP PKRAAPSGPA RSSGGGMRGR ALAVRGRDGY SGPPRREPLP PRRDPYLGPR DEGYSSRDGY SSRDYREPRG FAPSPGEYTH RDYGHSSVRD DCPLRGYSDR DGYGGRDRDY GDHLSRGSHR EPFESYGELR GAAPGRGTPP SYGGGGRYEE YRGYSPDAYS GGRDSYSSSY GRSDRYSRGR HRVGRPDRGL SLSMERGCPP QRDSYSRSGC RVPRGGGRLG GRLERGGGRS RY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards