About TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (TAF5L) is a protein
from Homo sapiens identified by UniProt accession
O75529, 589 residues long.
MolForge cross-references it against 0 known binders and
23 disease associations.
Target properties
| Protein name | TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L |
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| UniProt accession | O75529 |
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| Gene | TAF5L |
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| Organism | Homo sapiens |
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| Length | 589 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (23)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.31
- mean corpuscular volume · score 0.27
- mean corpuscular hemoglobin concentration · score 0.26
- breast adenocarcinoma · score 0.22
- mean corpuscular hemoglobin · score 0.22
- erythrocyte count · score 0.19
- red blood cell density measurement · score 0.19
- body height · score 0.13
- genetic disorder · score 0.12
- mean reticulocyte volume · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75529-F1 | alphafold | PREDICTED | 76.16 | — |
Amino-acid sequence (589 residues)
MKRVRTEQIQ MAVSCYLKRR QYVDSDGPLK QGLRLSQTAE EMAANLTVQS ESGCANIVSA APCQAEPQQY EVQFGRLRNF LTDSDSQHSH EVMPLLYPLF VYLHLNLVQN SPKSTVESFY SRFHGMFLQN ASQKDVIEQL QTTQTIQDIL SNFKLRAFLD NKYVVRLQED SYNYLIRYLQ SDNNTALCKV LTLHIHLDVQ PAKRTDYQLY ASGSSSRSEN NGLEPPDMPS PILQNEAALE VLQESIKRVK DGPPSLTTIC FYAFYNTEQL LNTAEISPDS KLLAAGFDNS CIKLWSLRSK KLKSEPHQVD VSRIHLACDI LEEEDDEDDN AGTEMKILRG HCGPVYSTRF LADSSGLLSC SEDMSIRYWD LGSFTNTVLY QGHAYPVWDL DISPYSLYFA SGSHDRTARL WSFDRTYPLR IYAGHLADVD CVKFHPNSNY LATGSTDKTV RLWSAQQGNS VRLFTGHRGP VLSLAFSPNG KYLASAGEDQ RLKLWDLASG TLYKELRGHT DNITSLTFSP DSGLIASASM DNSVRVWDIR NTYCSAPADG SSSELVGVYT GQMSNVLSVQ FMACNLLLVT GITQENQEH
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