Polycomb protein EED (EED)

About Polycomb protein EED

Polycomb protein EED (EED) is a protein from Homo sapiens identified by UniProt accession O75530, 441 residues long. MolForge cross-references it against 0 known binders and 247 disease associations.

Target properties

Protein name	Polycomb protein EED
UniProt accession	O75530
Gene	EED
Organism	Homo sapiens
Length	441 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (247)

Diseases linked to this target (Open Targets).

Cohen-Gibson syndrome · score 0.78
viral disease · score 0.46
melanoma · score 0.42
breast carcinoma · score 0.42
cancer · score 0.38
platelet component distribution width · score 0.33
acute myeloid leukemia · score 0.30
breast adenocarcinoma · score 0.28
head and neck squamous cell carcinoma · score 0.28
autism spectrum disorder · score 0.27

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75530-F1	alphafold	PREDICTED	86.48	—

Amino-acid sequence (441 residues)

MSEREVSTAP AGTDMPAAKK QKLSSDENSN PDLSGDENDD AVSIESGTNT ERPDTPTNTP NAPGRKSWGK GKWKSKKCKY SFKCVNSLKE DHNQPLFGVQ FNWHSKEGDP LVFATVGSNR VTLYECHSQG EIRLLQSYVD ADADENFYTC AWTYDSNTSH PLLAVAGSRG IIRIINPITM QCIKHYVGHG NAINELKFHP RDPNLLLSVS KDHALRLWNI QTDTLVAIFG GVEGHRDEVL SADYDLLGEK IMSCGMDHSL KLWRINSKRM MNAIKESYDY NPNKTNRPFI SQKIHFPDFS TRDIHRNYVD CVRWLGDLIL SKSCENAIVC WKPGKMEDDI DKIKPSESNV TILGRFDYSQ CDIWYMRFSM DFWQKMLALG NQVGKLYVWD LEVEDPHKAK CTTLTHHKCG AAIRQTSFSR DSSILIAVCD DASIWRWDRL R

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards