Barrier-to-autointegration factor (BANF1)

About Barrier-to-autointegration factor

Barrier-to-autointegration factor (BANF1) is a protein from Homo sapiens identified by UniProt accession O75531, 89 residues long. MolForge cross-references it against 0 known binders and 188 disease associations.

Target properties

Protein name	Barrier-to-autointegration factor
UniProt accession	O75531
Gene	BANF1
Organism	Homo sapiens
Length	89 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (188)

Diseases linked to this target (Open Targets).

Nestor-Guillermo progeria syndrome · score 0.60
HIV infection · score 0.58
neurodegenerative disease · score 0.44
neoplasm · score 0.10
body height · score 0.09
blood protein measurement · score 0.09
cerebrospinal fluid biomarker measurement · score 0.08
neuroblastoma · score 0.08
triple-negative breast cancer · score 0.08
infection · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75531-F1	alphafold	PREDICTED	96.78	—

Amino-acid sequence (89 residues)

MTTSQKHRDF VAEPMGEKPV GSLAGIGEVL GKKLEERGFD KAYVVLGQFL VLKKDEDLFR EWLKDTCGAN AKQSRDCFGC LREWCDAFL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards