About Disabled homolog 1
Disabled homolog 1 (DAB1) is a protein
from Homo sapiens identified by UniProt accession
O75553, 588 residues long.
MolForge cross-references it against 0 known binders and
182 disease associations.
Target properties
| Protein name | Disabled homolog 1 |
|---|
| UniProt accession | O75553 |
|---|
| Gene | DAB1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 588 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (182)
Diseases linked to this target (Open Targets).
- spinocerebellar ataxia type 37 · score 0.52
- mathematical ability · score 0.42
- cortical thickness · score 0.37
- self reported educational attainment · score 0.35
- attention deficit hyperactivity disorder · score 0.34
- antisocial behaviour measurement · score 0.34
- substance abuse · score 0.34
- brain measurement · score 0.32
- neuroimaging measurement · score 0.32
- cortical surface area measurement · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75553-F1 | alphafold | PREDICTED | 58.62 | — |
Amino-acid sequence (588 residues)
MSTETELQVA VKTSAKKDSR KKGQDRSEAT LIKRFKGEGV RYKAKLIGID EVSAARGDKL CQDSMMKLKG VVAGARSKGE HKQKIFLTIS FGGIKIFDEK TGALQHHHAV HEISYIAKDI TDHRAFGYVC GKEGNHRFVA IKTAQAAEPV ILDLRDLFQL IYELKQREEL EKKAQKDKQC EQAVYQTILE EDVEDPVYQY IVFEAGHEPI RDPETEENIY QVPTSQKKEG VYDVPKSQPV SNGYSFEDFE ERFAAATPNR NLPTDFDEIF EATKAVTQLE LFGDMSTPPD ITSPPTPATP GDAFIPSSSQ TLPASADVFS SVPFGTAAVP SGYVAMGAVL PSFWGQQPLV QQQMVMGAQP PVAQVMPGAQ PIAWGQPGLF PATQQPWPTV AGQFPPAAFM PTQTVMPLPA AMFQGPLTPL ATVPGTSDST RSSPQTDKPR QKMGKETFKD FQMAQPPPVP SRKPDQPSLT CTSEAFSSYF NKVGVAQDTD DCDDFDISQL NLTPVTSTTP STNSPPTPAP RQSSPSKSSA SHASDPTTDD IFEEGFESPS KSEEQEAPDG SQASSNSDPF GEPSGEPSGD NISPQAGS
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