WW domain-binding protein 4 (WBP4)

About WW domain-binding protein 4

WW domain-binding protein 4 (WBP4) is a protein from Homo sapiens identified by UniProt accession O75554, 376 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.

Target properties

Protein name	WW domain-binding protein 4
UniProt accession	O75554
Gene	WBP4
Organism	Homo sapiens
Length	376 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (34)

Diseases linked to this target (Open Targets).

Neurodevelopmental disorder · score 0.39
neurodegenerative disease · score 0.34
serum alanine aminotransferase measurement · score 0.33
aspartate aminotransferase measurement · score 0.32
total cholesterol measurement · score 0.29
high density lipoprotein cholesterol measurement · score 0.26
serum gamma-glutamyl transferase measurement · score 0.24
alkaline phosphatase measurement · score 0.23
apolipoprotein A 1 measurement · score 0.22
intraocular pressure measurement · score 0.20

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75554-F1	alphafold	PREDICTED	65.89	—

Amino-acid sequence (376 residues)

MADYWKSQPK KFCDYCKCWI ADNRPSVEFH ERGKNHKENV AKRISEIKQK SLDKAKEEEK ASKEFAAMEA AALKAYQEDL KRLGLESEIL EPSITPVTST IPPTSTSNQQ KEKKEKKKRK KDPSKGRWVE GITSEGYHYY YDLISGASQW EKPEGFQGDL KKTAVKTVWV EGLSEDGFTY YYNTETGESR WEKPDDFIPH TSDLPSSKVN ENSLGTLDES KSSDSHSDSD GEQEAEEGGV STETEKPKIK FKEKNKNSDG GSDPETQKEK SIQKQNSLGS NEEKSKTLKK SNPYGEWQEI KQEVESHEEV DLELPSTENE YVSTSEADGG GEPKVVFKEK TVTSLGVMAD GVAPVFKKRR TENGKSRNLR QRGDDQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards