About Jerky protein homolog
Jerky protein homolog (JRK) is a protein
from Homo sapiens identified by UniProt accession
O75564, 556 residues long.
MolForge cross-references it against 0 known binders and
47 disease associations.
Target properties
| Protein name | Jerky protein homolog |
|---|
| UniProt accession | O75564 |
|---|
| Gene | JRK |
|---|
| Organism | Homo sapiens |
|---|
| Length | 556 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (47)
Diseases linked to this target (Open Targets).
- gastric carcinoma · score 0.32
- duodenal ulcer · score 0.27
- urinary bladder carcinoma · score 0.26
- gastric ulcer · score 0.24
- urinary bladder cancer · score 0.23
- body mass index · score 0.23
- atrophic gastritis · score 0.23
- Malignant Urinary System Neoplasm · score 0.22
- gastric cancer · score 0.22
- body fat percentage · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75564-F1 | alphafold | PREDICTED | 70.80 | — |
Amino-acid sequence (556 residues)
MASKPAAGKS RGEKRKRVVL TLKEKIDICT RLEKGESRKA LMQEYNVGMS TLYDIRAHKA QLLRFFASSD SNKALEQRRT LHTPKLEHLD RVLYEWFLGK RSEGVPVSGP MLIEKAKDFY EQMQLTEPCV FSGGWLWRFK ARHGIKKLDA SSEKQSADHQ AAEQFCAFFR SLAAEHGLSA EQVYNADETG LFWRCLPNPT PEGGAVPGPK QGKDRLTVLM CANATGSHRL KPLAIGKCSG PRAFKGIQHL PVAYKAQGNA WVDKEIFSDW FHHIFVPSVR EHFRTIGLPE DSKAVLLLDS SRAHPQEAEL VSSNVFTIFL PASVASLVQP MEQGIRRDFM RNFINPPVPL QGPHARYNMN DAIFSVACAW NAVPSHVFRR AWRKLWPSVA FAEGSSSEEE LEAECFPVKP HNKSFAHILE LVKEGSSCPG QLRQRQAASW GVAGREAEGG RPPAATSPAE VVWSSEKTPK ADQDGRGDPG EGEEVAWEQA AVAFDAVLRF AERQPCFSAQ EVGQLRALRA VFRSQQQETV GLEDVVVTSP EELAIPKCCL EASTET
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