About Peptide chain release factor 1, mitochondrial
Peptide chain release factor 1, mitochondrial (MTRF1) is a protein
from Homo sapiens identified by UniProt accession
O75570, 445 residues long.
MolForge cross-references it against 0 known binders and
13 disease associations.
Target properties
| Protein name | Peptide chain release factor 1, mitochondrial |
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| UniProt accession | O75570 |
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| Gene | MTRF1 |
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| Organism | Homo sapiens |
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| Length | 445 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (13)
Diseases linked to this target (Open Targets).
- hypertriglyceridemia 2 · score 0.06
- systolic blood pressure · score 0.06
- cholesterol-ester transfer protein deficiency · score 0.05
- Fish-eye disease · score 0.05
- hypoalphalipoproteinemia, primary, 1 · score 0.04
- hypertension · score 0.04
- hyperlipidemia due to hepatic triglyceride lipase deficiency · score 0.04
- homozygous familial hypercholesterolemia · score 0.04
- Combined hyperlipidemia · score 0.04
- diet measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75570-F1 | alphafold | PREDICTED | 80.51 | — |
Amino-acid sequence (445 residues)
MNRHLCVWLF RHPSLNGYLQ CHIQLHSHQF RQIHLDTRLQ VFRQNRNCIL HLLSKNWSRR YCHQDTKMLW KHKALQKYME NLSKEYQTLE QCLQHIPVNE ENRRSLNRRH AELAPLAAIY QEIQETEQAI EELESMCKSL NKQDEKQLQE LALEERQTID QKINMLYNEL FQSLVPKEKY DKNDVILEVT AGRTTGGDIC QQFTREIFDM YQNYSCYKHW QFELLNYTPA DYGGLHHAAA RISGDGVYKH LKYEGGIHRV QRIPEVGLSS RMQRIHTGTM SVIVLPQPDE VDVKLDPKDL RIDTFRAKGA GGQHVNKTDS AVRLVHIPTG LVVECQQERS QIKNKEIAFR VLRARLYQQI IEKDKRQQQS ARKLQVGTRA QSERIRTYNF TQDRVSDHRI AYEVRDIKEF LCGGKGLDQL IQRLLQSADE EAIAELLDEH LKSAK
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