DNA-directed RNA polymerase III subunit RPC9 (CRCP)

About DNA-directed RNA polymerase III subunit RPC9

DNA-directed RNA polymerase III subunit RPC9 (CRCP) is a protein from Homo sapiens identified by UniProt accession O75575, 148 residues long. MolForge cross-references it against 0 known binders and 50 disease associations.

Target properties

Protein name	DNA-directed RNA polymerase III subunit RPC9
UniProt accession	O75575
Gene	CRCP
Organism	Homo sapiens
Length	148 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (50)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.33
body height · score 0.28
neutrophil count · score 0.22
endometrial cancer · score 0.18
total blood protein measurement · score 0.16
myeloid white cell count · score 0.09
blood protein measurement · score 0.09
leukocyte count · score 0.08
Parkinson disease · score 0.06
Griscelli syndrome type 3 · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-O75575-F1	alphafold	PREDICTED	82.90	—

Amino-acid sequence (148 residues)

MEVKDANSAL LSNYEVFQLL TDLKEQRKES GKNKHSSGQQ NLNTITYETL KYISKTPCRH QSPEIVREFL TALKSHKLTK AEKLQLLNHR PVTAVEIQLM VEESEERLTE EQIEALLHTV TSILPAEPEA EQKKNTNSNV AMDEEDPA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards