About Ribosomal protein S6 kinase alpha-5
Ribosomal protein S6 kinase alpha-5 (RPS6KA5) is a protein
from Homo sapiens identified by UniProt accession
O75582, 802 residues long.
MolForge cross-references it against 0 known binders and
161 disease associations.
Target properties
| Protein name | Ribosomal protein S6 kinase alpha-5 |
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| UniProt accession | O75582 |
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| Gene | RPS6KA5 |
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| Organism | Homo sapiens |
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| Length | 802 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (8)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (161)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.50
- bone quantitative ultrasound measurement · score 0.46
- alkaline phosphatase measurement · score 0.46
- bone density · score 0.46
- blood phosphate measurement · score 0.41
- femoral neck bone mineral density · score 0.40
- lean body mass · score 0.40
- body mass index · score 0.40
- fat body mass · score 0.36
- BMI-adjusted waist-hip ratio · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-O75582-F1 | alphafold | PREDICTED | 69.96 | — |
Amino-acid sequence (802 residues)
MEEEGGSSGG AAGTSADGGD GGEQLLTVKH ELRTANLTGH AEKVGIENFE LLKVLGTGAY GKVFLVRKIS GHDTGKLYAM KVLKKATIVQ KAKTTEHTRT ERQVLEHIRQ SPFLVTLHYA FQTETKLHLI LDYINGGELF THLSQRERFT EHEVQIYVGE IVLALEHLHK LGIIYRDIKL ENILLDSNGH VVLTDFGLSK EFVADETERA YSFCGTIEYM APDIVRGGDS GHDKAVDWWS LGVLMYELLT GASPFTVDGE KNSQAEISRR ILKSEPPYPQ EMSALAKDLI QRLLMKDPKK RLGCGPRDAD EIKEHLFFQK INWDDLAAKK VPAPFKPVIR DELDVSNFAE EFTEMDPTYS PAALPQSSEK LFQGYSFVAP SILFKRNAAV IDPLQFHMGV ERPGVTNVAR SAMMKDSPFY QHYDLDLKDK PLGEGSFSIC RKCVHKKSNQ AFAVKIISKR MEANTQKEIT ALKLCEGHPN IVKLHEVFHD QLHTFLVMEL LNGGELFERI KKKKHFSETE ASYIMRKLVS AVSHMHDVGV VHRDLKPENL LFTDENDNLE IKIIDFGFAR LKPPDNQPLK TPCFTLHYAA PELLNQNGYD ESCDLWSLGV ILYTMLSGQV PFQSHDRSLT CTSAVEIMKK IKKGDFSFEG EAWKNVSQEA KDLIQGLLTV DPNKRLKMSG LRYNEWLQDG SQLSSNPLMT PDILGSSGAA VHTCVKATFH AFNKYKREGF CLQNVDKAPL AKRRKMKKTS TSTETRSSSS ESSHSSSSHS HGKTTPTKTL QPSNPADSNN PETLFQFSDS VA
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